San Francisco 49ers place TE George Kittle on injured reserve

The San Francisco 49ers have placed George Kittle on injured reserve, ruling the tight end out for at least three games due to his calf injury.

Kittle has been playing through the injury since suffering it in Week 1 against the Detroit Lions. But he did not participate in practice all week and had been considered doubtful for Sunday’s game against the Arizona Cardinals before the IR move.

It’s another major change to the 49ers offense, which will start rookie Trey Lance at quarterback for the first time with Jimmy Garoppolo also out with a calf injury.

Kittle, a two-time Pro Bowler, ranks second on the 49ers with 19 receptions and 227 yards this season.

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